TARGETID

T99204

FORMERID

TTDR00445

UNIPROID

PSN2_HUMAN

TARGNAME

Presenilin 2 (PSEN2)

GENENAME

PSEN2

TARGTYPE

Clinical trial target

SYNONYMS

STM2; STM-2; Presenilin-2; PSNL2; PS-2; E5-1; AD5; AD4; AD3LP

FUNCTION

Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.23.-

SEQUENCE

MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

DRUGINFO

(S)-FLURBIPROFEN

DRUGINFO

R-flurbiprofen

DRUGINFO

(2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone

DRUGINFO

(5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone

DRUGINFO

(5R,6S)-6-(benzyloxy)-5-methoxycyclohex-2-enone

DRUGINFO

1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one

DRUGINFO

1-Chloro-4-(1-phenyl-cyclohexanesulfonyl)-benzene

DRUGINFO

Drug 311383

DRUGINFO

Drug 311440