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靶点信息17(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Inflammation-related GPCR EX33 (GPR84)
TARGTYPE
Clinical trial target
SYNONYMS
Inflammation-related G-protein coupled receptor EX33; G-protein coupled receptor 84; EX33
FUNCTION
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
SEQUENCE
MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
DRUGINFO
2-hydroxy capric acid
DRUGINFO
2-hydroxylauric acid
DRUGINFO
3-hydroxy capric acid
DRUGINFO
3-hydroxylauric acid
DRUGINFO
6-n-octylaminouracil
目标的蛋白质ID
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| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Inflammation-related GPCR EX33 (GPR84) |
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