靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T98062

FORMERID

TTDC00099

UNIPROID

PYGM_HUMAN

TARGNAME

Glycogen phosphorylase muscle form (GP)

GENENAME

PYGM

TARGTYPE

Patented-recorded target

SYNONYMS

Muscle glycogen phosphorylase; Glycogen phosphorylase, muscle form; Glycogen phosphorylase b

FUNCTION

Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism.

PDBSTRUC

1Z8D

BIOCLASS

Glycosyltransferases

ECNUMBER

EC 2.4.1.1

SEQUENCE

MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI

DRUGINFO

D07LUJ

URSOLIC ACID

Phase 2

DRUGINFO

D09HAL

JTT-651

Discontinued in Phase 1

DRUGINFO

D0J6KJ

1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose

Investigative

DRUGINFO

D02AFI

1-D-glucopyranosyl cytosine

Investigative

DRUGINFO

D0P1XH

1-D-glucopyranosyl uracil

Investigative

DRUGINFO

D0I9PG

1-N-Acetyl-Beta-D-Glucosamine

Investigative

DRUGINFO

D06YDW

23-hydroxybetulinic acid

Investigative

DRUGINFO

D0X5YM

2alpha-Hydroxyolean-12-en-28-oic acid

Investigative

目标的 KEGG 通路数据

标题	内容
hsa00500	Starch and sucrose metabolism
hsa01100	Metabolic pathways
hsa04910	Insulin signaling pathway
hsa04922	Glucagon signaling pathway

目标的 Wiki 路径数据

标题	内容
WP500	Glycogen Metabolism
WP1848	Metabolism of carbohydrates

目标的蛋白质ID

标题	内容
TARGETID	T98062
UNIPROID	PYGM_HUMAN
TARGNAME	Glycogen phosphorylase muscle form (GP)
TARGTYPE	Patented target

目标的序列数据

标题	内容
Glycogen phosphorylase muscle form (GP)	MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI

标题

内容

Glycogen phosphorylase muscle form (GP)

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