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靶点信息36(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Carboxypeptidase B2 (CPB2)
TARGTYPE
Clinical trial target
SYNONYMS
Thrombin-activable fibrinolysis inhibitor; TAFI; Plasma carboxypeptidase B; Carboxypeptidase U; CPU; CPB2
FUNCTION
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
PDBSTRUC
5HVH; 5HVG; 5HVF; 4P10; 3LMS
SEQUENCE
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
DRUGINFO
(+/-)-5-amino-2-(mercaptomethyl)pentanoic acid
DRUGINFO
2-(3-aminophenyl)-3-mercaptopropanoic acid
DRUGINFO
2-(3-guanidinophenyl)-3-mercaptopropanoic acid
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04610 |
|
| hsa04972 |
|
| hsa04974 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Carboxypeptidase B2 (CPB2) |
|