靶点信息31(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Macrophage inflammatory protein 1-alpha (CCL3)
TARGTYPE
Clinical trial target
SYNONYMS
Tonsillar lymphocyte LD78 alpha protein; Small-inducible cytokine A3; SIS-beta; SCYA3; PAT 464.1; Macrophage Inflammatory Protein-1alpha Nuclear Protein; MNP; MIP1A; MIP-1-alpha; G0S19-1 protein; G0S19-1; G0/G1 switch regulatory protein 19-1; C-C motif chemokine 3
FUNCTION
Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Monokine with inflammatory and chemokinetic properties.
PDBSTRUC
5D65; 5COR; 4ZKB; 4RA8; 3KBX
BIOCLASS
Cytokine: CC chemokine
SEQUENCE
MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04062:Chemokine signaling pathway
KEGGPATH
hsa04620:Toll-like receptor signaling pathway
KEGGPATH
hsa05132:Salmonella infection
KEGGPATH
hsa05142:Chagas disease (American trypanosomiasis)
KEGGPATH
hsa05323:Rheumatoid arthritis
WIKIPATH
WP1449:Regulation of toll-like receptor signaling pathway
WIKIPATH
WP1825:GPCR ligand binding
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04062 |
|
| hsa04620 |
|
| hsa05132 |
|
| hsa05142 |
|
| hsa05323 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP615 |
|
| WP1825 |
|
| WP1449 |
|
| WP75 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Macrophage inflammatory protein 1-alpha (CCL3) |
|