靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T97713

FORMERID

TTDS00401

UNIPROID

PUR1_HUMAN

TARGNAME

Amidophosphoribosyltransferase (PPAT)

GENENAME

PPAT

TARGTYPE

Successful target

SYNONYMS

Glutamine phosphoribosylpyrophosphate amidotransferase; GPAT; ATase

FUNCTION

Catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) into 5-phosphoribosyl-1-amine (PRA), using the amine group from a glutamine side-chain.

BIOCLASS

Short-chain dehydrogenases reductase

ECNUMBER

EC 2.4.2.14

SEQUENCE

MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW

DRUGINFO

Azathioprine

DRUGINFO

Mercaptopurine

DRUGINFO

6-Chloropurine Riboside, 5'-Monophosphate

Investigative

DRUGINFO

D0T4UE

Mycophenolic bis(sulfonamide)

Investigative

DRUGINFO

D01LDQ

Mycophenolic hydroxamic acid

Investigative

DRUGINFO

D0S4BK

Tiazofurin adenine dinucleotide

Investigative

KEGGPATH

hsa00230:Purine metabolism

KEGGPATH

hsa00983:Drug metabolism - other enzymes

KEGGPATH

hsa01100:Metabolic pathways

目标的 KEGG 通路数据

标题	内容
hsa00230	Purine metabolism
hsa00983	Drug metabolism - other enzymes
hsa01100	Metabolic pathways

目标的 Wiki 路径数据

标题	内容
WP404	Nucleotide Metabolism

目标的蛋白质ID

标题	内容
TARGETID	T97713
UNIPROID	PUR1_HUMAN
TARGNAME	Amidophosphoribosyltransferase (PPAT)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Amidophosphoribosyltransferase (PPAT)	MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW

标题

内容

Amidophosphoribosyltransferase (PPAT)

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