TARGETID

T97035

FORMERID

TTDS00373

UNIPROID

TYRO_HUMAN

TARGNAME

Tyrosinase (TYR)

GENENAME

TYR

TARGTYPE

Successful target

SYNONYMS

Tumor rejection antigen AB; SK29-AB; Monophenol monooxygenase; LB24-AB

FUNCTION

Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

BIOCLASS

Paired donor oxygen oxidoreductase

ECNUMBER

EC 1.14.18.1

SEQUENCE

MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

DRUGINFO

Hydroquinone

DRUGINFO

Monobenzone

DRUGINFO

Melanoma vaccine

DRUGINFO

Multi-epitope peptide melanoma vaccine

DRUGINFO

MKC-1106-MT

DRUGINFO

Multi-epitope tyrosinase/gp100 vaccine

DRUGINFO

Polynoma-1

DRUGINFO

3-(phenoxymethyl) benzylamine derivative 1

DRUGINFO

3-(phenoxymethyl) benzylamine derivative 2