靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T96685

UNIPROID

HXK2_HUMAN

TARGNAME

Hexokinase-2 (HK2)

GENENAME

HK2

TARGTYPE

Clinical trial target

SYNONYMS

Muscle form hexokinase; Hexokinase type II; HK II

FUNCTION

cytosol, membrane, mitochondrial outer membrane, fructokinase activity, glucokinase activity, hexokinase activity, mannokinase activity, apoptotic mitochondrial changes, canonical glycolysis, cellular glucose homeostasis.

PDBSTRUC

5HG1; 5HFU; 5HEX; 2NZT

BIOCLASS

Hexokinase family

ECNUMBER

EC 2.7.1.1

SEQUENCE

MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR

DRUGINFO

D06QBX

VDA-1102

Phase 2

KEGGPATH

hsa00010:Glycolysis/Gluconeogenesis

KEGGPATH

hsa00051:Fructose and mannose metabolism

KEGGPATH

hsa00052:Galactose metabolism

KEGGPATH

hsa00500:Starch and sucrose metabolism

KEGGPATH

hsa00520:Amino sugar and nucleotide sugar metabolism

KEGGPATH

hsa00524:Neomycin, kanamycin and gentamicin biosynthesis

KEGGPATH

hsa01100:Metabolic pathways

KEGGPATH

hsa01200:Carbon metabolism

目标的 KEGG 通路数据

标题	内容
hsa00010	Glycolysis/Gluconeogenesis
hsa00051	Fructose and mannose metabolism
hsa00052	Galactose metabolism
hsa00500	Starch and sucrose metabolism
hsa00520	Amino sugar and nucleotide sugar metabolism
hsa00524	Neomycin, kanamycin and gentamicin biosynthesis
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa04066	HIF-1 signaling pathway
hsa04910	Insulin signaling pathway
hsa04930	Type II diabetes mellitus
hsa04973	Carbohydrate digestion and absorption
hsa05230	Central carbon metabolism in cancer

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T96685
UNIPROID	HXK2_HUMAN
TARGNAME	Hexokinase-2 (HK2)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Hexokinase-2 (HK2)	MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR

标题

内容

Hexokinase-2 (HK2)

最新招商产品更多>>