TARGETID

T88752

FORMERID

TTDI02365

UNIPROID

RAC1_HUMAN

TARGNAME

Ras-related C3 botulinum toxin substrate 1 (RAC1)

GENENAME

RAC1

TARGTYPE

Literature-reported target

SYNONYMS

Cell migration-inducing gene5 protein

FUNCTION

In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states.

PDBSTRUC

6BC1; 6AGP; 5O33; 5N6O; 5HZH

BIOCLASS

Small GTPase

ECNUMBER

EC 3.6.5.2

SEQUENCE

MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL

DRUGINFO

EHT-1864

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04014:Ras signaling pathway

KEGGPATH

hsa04015:Rap1 signaling pathway

KEGGPATH

hsa04024:cAMP signaling pathway

KEGGPATH

hsa04062:Chemokine signaling pathway

KEGGPATH

hsa04071:Sphingolipid signaling pathway

KEGGPATH

hsa04145:Phagosome