靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T83797

FORMERID

TTDC00194

UNIPROID

HGF_HUMAN

TARGNAME

Hepatocyte growth factor (HGF)

GENENAME

HGF

TARGTYPE

Clinical trial target

SYNONYMS

Scatter factor; SF; Hepatopoietin-A; Hepatopoeitin A; HPTA

FUNCTION

Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types.

PDBSTRUC

5CT3; 5CT2; 5CT1; 5CSQ; 5CS9

BIOCLASS

Peptidase

SEQUENCE

MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS

DRUGINFO

D9CI7V

Donaperminogene seltoplasmid

DRUGINFO

VM-202

DRUGINFO

Ficlatuzumab

DRUGINFO

MP0250

DRUGINFO

ABI-011

DRUGINFO

TAK-701

DRUGINFO

Rilotumumab

Discontinued in Phase 2

DRUGINFO

D0B0SV

N,O6-Disulfo-Glucosamine

Investigative

DRUGINFO

D06VYT

O2-Sulfo-Glucuronic Acid

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04151	PI3K-Akt signaling pathway
hsa04510	Focal adhesion
hsa05144	Malaria
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05211	Renal cell carcinoma
hsa05218	Melanoma

目标的 Wiki 路径数据

标题	内容
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP306	Focal Adhesion
WP2884	NRF2 pathway
WP2882	Nuclear Receptors Meta-Pathway
WP2870	Extracellular vesicle-mediated signaling in recipient cells
WP2848	Differentiation Pathway
WP2673	Interleukin-7 signaling
WP2263	Prostate Cancer

目标的蛋白质ID

标题	内容
TARGETID	T83797
UNIPROID	HGF_HUMAN
TARGNAME	Hepatocyte growth factor (HGF)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Hepatocyte growth factor (HGF)	MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS

标题

内容

Hepatocyte growth factor (HGF)

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