TARGETID

T83011

FORMERID

TTDS00341

UNIPROID

AOFB_HUMAN

TARGNAME

Monoamine oxidase type B (MAO-B)

GENENAME

MAOB

TARGTYPE

Successful target

SYNONYMS

MAO-B; Amine oxidase [flavin-containing] B

FUNCTION

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

PDBSTRUC

6FWC; 6FW0; 6FVZ; 5MRL; 4CRT

BIOCLASS

CH-NH(2) donor oxidoreductase

ECNUMBER

EC 1.4.3.4

SEQUENCE

MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

DRUGINFO

Budipine

DRUGINFO

Indeloxazine

DRUGINFO

Pargyline

DRUGINFO

Phenelzine

DRUGINFO

Rasagiline

DRUGINFO

Safinamide

DRUGINFO

Safinamide mesylate

DRUGINFO

Selegiline