TARGETID

T82723

FORMERID

TTDR00292

UNIPROID

FABF_ECOLI

TARGNAME

Bacterial Oxoacyl-[acyl-carrier-protein] synthase II (Bact fabF)

GENENAME

Bact fabF

TARGTYPE

Literature-reported target

SYNONYMS

KASB; KAS II; KAS 2; FabF; Condensing enzyme FabF; Beta-ketoacyl-acyl carrier protein synthase B; Beta-ketoacyl-ACP synthase II; Beta-ketoacyl-ACP synthase 2; 3-oxoacyl-[acyl-carrier-protein] synthase 2

FUNCTION

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.

PDBSTRUC

3I8P; 3HO9; 3HO2; 3HNZ; 3G11

BIOCLASS

Acyltransferase

ECNUMBER

EC 2.3.1.179

SEQUENCE

MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCEDIISRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHTSLMNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAYGDADVMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLVLEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGYVNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRDQAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI

DRUGINFO

Lauric Acid

DRUGINFO

PLATENSIMYCIN

DRUGINFO

Thiolactomycin