TARGETID

T82668

FORMERID

TTDI02559

UNIPROID

AADAT_HUMAN

TARGNAME

Kynurenine oxoglutarate transaminase II (AADAT)

GENENAME

AADAT

TARGTYPE

Preclinical target

SYNONYMS

Kynurenineoxoglutarate transaminase II; Kynurenineoxoglutarate transaminase 2; Kynurenineoxoglutarate aminotransferase II; Kynurenine/alphaaminoadipate aminotransferase, mitochondrial; Kynurenine aminotransferase II; KAT/AadAT; Alphaaminoadipate aminotransferase; AadAT; 2aminoadipate transaminase; 2aminoadipate aminotransferase

FUNCTION

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

PDBSTRUC

6D0A; 5TF5; 5EUN; 5EFS; 4GEB

BIOCLASS

Transaminase

ECNUMBER

EC 2.6.1.39

SEQUENCE

MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL

DRUGINFO

US10065972, Example 281

DRUGINFO

US10065972, Example 396

DRUGINFO

US10065972, Example 560

DRUGINFO

US8933095, 1

DRUGINFO

US8933095, 14

DRUGINFO

US8933095, 16

DRUGINFO

US8933095, 18

DRUGINFO

(S)-4-(Ethylsulfonyl)benzoylalanine