靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

REACPATH

R-HSA-446652:Interleukin-1 signaling

REACPATH

R-HSA-5357905:Regulation of TNFR1 signaling

REACPATH

R-HSA-5357956:TNFR1-induced NFkappaB signaling pathway

REACPATH

R-HSA-5602636:IKBKB deficiency causes SCID

REACPATH

R-HSA-5603027:IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)

REACPATH

R-HSA-5603029:IkBA variant leads to EDA-ID

REACPATH

R-HSA-5607764:CLEC7A (Dectin-1) signaling

REACPATH

R-HSA-5684264:MAP3K8 (TPL2)-dependent MAPK1/3 activation

REACPATH

R-HSA-933542:TRAF6 mediated NF-kB activation

REACPATH

R-HSA-933543:NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

REACPATH

R-HSA-937039:IRAK1 recruits IKK complex

REACPATH

R-HSA-937041:IKK complex recruitment mediated by RIP1

REACPATH

R-HSA-975144:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

INTEPATH

bcr_5pathway:BCR signaling pathway

INTEPATH

cd8tcrpathway:TCR signaling in naïve CD8+ T cells

INTEPATH

faspathway:FAS (CD95) signaling pathway

INTEPATH

fcer1pathway:Fc-epsilon receptor I signaling in mast cells

INTEPATH

foxopathway:FoxO family signaling

INTEPATH

gmcsf_pathway:GMCSF-mediated signaling events

INTEPATH

il1pathway:IL1-mediated signaling events

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04014	Ras signaling pathway
hsa04062	Chemokine signaling pathway
hsa04064	NF-kappa B signaling pathway
hsa04068	FoxO signaling pathway
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04210	Apoptosis
hsa04380	Osteoclast differentiation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04668	TNF signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04910	Insulin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa04930	Type II diabetes mellitus
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05131	Shigellosis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05160	Hepatitis C
hsa05161	Hepatitis B
hsa05164	Influenza A
hsa05166	HTLV-I infection
hsa05168	Herpes simplex infection
hsa05169	Epstein-Barr virus infection
hsa05200	Pathways in cancer
hsa05206	MicroRNAs in cancer
hsa05212	Pancreatic cancer
hsa05215	Prostate cancer
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05222	Small cell lung cancer

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP712	Estrogen signaling pathway
WP69	TCR Signaling Pathway
WP481	Insulin Signaling
WP395	IL-4 Signaling Pathway
WP382	MAPK Signaling Pathway
WP288	NLR Proteins
WP2804	Hair Follicle Development: Induction (Part 1 of 3)
WP2801	MyD88 cascade initiated on plasma membrane
WP2795	Cardiac Hypertrophic Response
WP2794	Cytosolic sensors of pathogen-associated DNA
WP2768	MyD88 dependent cascade initiated on endosome
WP2763	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
WP2761	MyD88:Mal cascade initiated on plasma membrane
WP2759	Fc epsilon receptor (FCERI) signaling
WP2752	MyD88-independent cascade
WP2746	Signaling by the B Cell Receptor (BCR)
WP2656	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
WP2637	Structural Pathway of Interleukin 1 (IL-1)
WP262	EBV LMP1 signaling
WP2571	Polycystic Kidney Disease Pathway
WP254	Apoptosis
WP2435	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
WP2380	BDNF signaling pathway
WP2332	Interleukin-11 Signaling Pathway
WP2324	AGE/RAGE pathway
WP231	TNF alpha Signaling Pathway
WP23	B Cell Receptor Signaling Pathway
WP2112	IL17 signaling pathway
WP2036	TWEAK Signaling Pathway
WP2034	Leptin signaling pathway
WP2018	RANKL/RANK Signaling Pathway
WP1976	Signalling by NGF
WP195	IL-1 signaling pathway
WP1927	TCR signaling
WP1904	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP1839	Interleukin-1 signaling
WP1772	Apoptosis Modulation and Signaling
WP1584	Type II diabetes mellitus
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP1449	Regulation of toll-like receptor signaling pathway
WP1434	Osteopontin Signaling
WP1433	NOD pathway

目标的蛋白质ID

标题	内容
TARGETID	T78429
UNIPROID	IKKB_HUMAN
TARGNAME	Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)	MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS

标题

内容

Inhibitor of nuclear factor kappa-B kinase beta (IKKB)

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