TARGETID

T75440

FORMERID

TTDS00454

UNIPROID

TSPO_HUMAN

TARGNAME

Translocator protein (TSPO)

GENENAME

TSPO

TARGTYPE

Successful target

SYNONYMS

Peripheral-type benzodiazepine receptor; Peripheral benzodiazepine receptor; PKBS; PBR; Mitochondrial benzodiazepine receptor; MBR; BZRP

FUNCTION

Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme.

BIOCLASS

Cholesterol/porphyrin uptake translocator

SEQUENCE

MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE

DRUGINFO

Adinazolam

DRUGINFO

Alpidem

DRUGINFO

Alprazolam

DRUGINFO

Chlordiazepoxide

DRUGINFO

Chlormezanone

DRUGINFO

Cinolazepam

DRUGINFO

Clorazepate

DRUGINFO

Clotiazepam

DRUGINFO

Diazepam

DRUGINFO

Estazolam