靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T74002

FORMERID

TTDR00322

UNIPROID

CSF2_HUMAN

TARGNAME

Granulocyte-macrophage colony-stimulating factor (CSF2)

GENENAME

CSF2

TARGTYPE

Successful target

SYNONYMS

Sargramostim; Molgramostin; GM-CSF; Colony-stimulating factor; CSF2; CSF

FUNCTION

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

PDBSTRUC

6BFS; 6BFQ; 5D72; 5D71; 5D70

BIOCLASS

Growth factor

SEQUENCE

MWLQSLLLLGTVACSISAPARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE

DRUGINFO

D05BXY

Talimogene Laherparepvec

DRUGINFO

JX-594

DRUGINFO

Cabiralizumab

DRUGINFO

GSK3196165

DRUGINFO

KB002/003

DRUGINFO

KB-003

DRUGINFO

Lenzilumab

DRUGINFO

Mavrilimumab

DRUGINFO

MT203

目标的 KEGG 通路数据

标题	内容
hsa04060	Cytokine-cytokine receptor interaction
hsa04630	Jak-STAT signaling pathway
hsa04640	Hematopoietic cell lineage
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04668	TNF signaling pathway
hsa05132	Salmonella infection
hsa05146	Amoebiasis
hsa05166	HTLV-I infection
hsa05202	Transcriptional misregulation in cancer
hsa05323	Rheumatoid arthritis

目标的 Wiki 路径数据

标题	内容
WP530	Cytokines and Inflammatory Response
WP2849	Hematopoietic Stem Cell Differentiation
WP2732	Interleukin-2 signaling
WP1840	Interleukin-3, 5 and GM-CSF signaling

目标的蛋白质ID

标题	内容
TARGETID	T74002
UNIPROID	CSF2_HUMAN
TARGNAME	Granulocyte-macrophage colony-stimulating factor (CSF2)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Granulocyte-macrophage colony-stimulating factor (CSF2)	MWLQSLLLLGTVACSISAPARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE

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