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靶点信息63(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Beta-secretase (BACE)
TARGTYPE
Clinical trial target
SYNONYMS
Transmembrane aspartic protease; Beta-site amyloid precursor protein cleaving enzyme; Beta-site AbetaPP-cleaving enzyme; BACE1
FUNCTION
Responsible for the proteolytic processing of the amyloid precursor protein (app). Cleaves at the amino terminus of the a-beta peptide sequence, between residues 671 and 672 of app, leads to the generation and extracellular release of beta-cleaved soluble liquid.
DRUGINFO
(S)-FLURBIPROFEN