靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T73724

FORMERID

TTDR00164

UNIPROID

ACHB4_HUMAN

TARGNAME

Neuronal acetylcholine receptor beta-4 (CHRNB4)

GENENAME

CHRNB4

TARGTYPE

Clinical trial target

SYNONYMS

CHRNB4; Beta-4 nAChR

FUNCTION

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

PDBSTRUC

2ASG

BIOCLASS

Neurotransmitter receptor

SEQUENCE

MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD

DRUGINFO

D08XPW

CYTISINE

Phase 3

DRUGINFO

D00ECO

SIB-1553A

Discontinued in Phase 2

DRUGINFO

D0C9KD

HOMOEPIBATIDINE

Terminated

DRUGINFO

D03YQY

(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol

Investigative

DRUGINFO

D00QCP

(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol

Investigative

DRUGINFO

D02FCS

15-nor-18-Methoxycornaridine

Investigative

DRUGINFO

D0U0LH

18-Dimethylaminocoronaridine

Investigative

DRUGINFO

D0VA5V

18-methoxycoronaridinate 2-Hydroxyethylamide

Investigative

DRUGINFO

D0WQ9A

18-methoxycoronaridinate 2-methoxyethylamide

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction
hsa04725	Cholinergic synapse

目标的 Wiki 路径数据

标题	内容
WP706	SIDS Susceptibility Pathways
WP2754	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP1603	Nicotine Activity on Chromaffin Cells

目标的蛋白质ID

标题	内容
TARGETID	T73724
UNIPROID	ACHB4_HUMAN
TARGNAME	Neuronal acetylcholine receptor beta-4 (CHRNB4)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Neuronal acetylcholine receptor beta-4 (CHRNB4)	MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD

标题

内容

Neuronal acetylcholine receptor beta-4 (CHRNB4)

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