靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T63967

UNIPROID

ACHA4_HUMAN; ACHB2_HUMAN

TARGNAME

Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2)

GENENAME

CHRNA4-CHRNB2

TARGTYPE

Successful target

SYNONYMS

CHRN; nAChR

FUNCTION

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.

BIOCLASS

Neurotransmitter receptor

SEQUENCE

MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI

DRUGINFO

Metocurine Iodide

DRUGINFO

Varenicline

DRUGINFO

AZD-1446

DRUGINFO

CP-601927

DRUGINFO

Sofinicline

DRUGINFO

TC-6499-12

DRUGINFO

SUVN 911

DRUGINFO

TC-2216

DRUGINFO

Dianicline

Discontinued in Phase 3

DRUGINFO

D0L1DP

ABT-089

Discontinued in Phase 2

DRUGINFO

D0AB4Q

Ispronicline

Discontinued in Phase 2

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T63967
UNIPROID	ACHA4_HUMAN; ACHB2_HUMAN
TARGNAME	Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2)	MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI

标题

内容

Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2)

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