TARGETID

T61657

FORMERID

TTDR01191

UNIPROID

RARB_HUMAN

TARGNAME

Retinoic acid receptor beta (RARB)

GENENAME

RARB

TARGTYPE

Successful target

SYNONYMS

RAR-epsilon; RAR-beta; Nuclear receptor subfamily 1 group B member 2; NR1B2; HBV-activated protein; HAP

FUNCTION

Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Receptor for retinoic acid.

PDBSTRUC

5UAN; 4JYI; 4JYH; 4JYG; 4DM8

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ

DRUGINFO

Alitretinoin

DRUGINFO

Tamibarotene

DRUGINFO

PMID27336223-Compound-10

DRUGINFO

PMID27336223-Compound-7

DRUGINFO

PMID27336223-Compound-8

DRUGINFO

AC261066

DRUGINFO

AC55649

DRUGINFO

AGN193109

DRUGINFO

BMS641