TARGETID

T60857

FORMERID

TTDR00033

UNIPROID

AK1C3_HUMAN

TARGNAME

Dihydrodiol dehydrogenase type I (AKR1C3)

GENENAME

AKR1C3

TARGTYPE

Successful target

SYNONYMS

Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Testosterone 17-beta-dehydrogenase 5; Prostaglandin F synthase; PGFS; KIAA0119; Indanol dehydrogenase; HSD17B5; HA1753; Dihydrodiol dehydrogenase 3; DDH1; DD3; DD-3; Chlordecone reductase homolog HAKRb; Aldo-keto reductase family 1 member C3; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type II, brain; 3-alpha-HSD type 2; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5

FUNCTION

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

PDBSTRUC

6GXK; 6F78; 6F2U; 5JM5; 5HNU

BIOCLASS

Short-chain dehydrogenases reductase

ECNUMBER

EC 1.-.-.-

SEQUENCE

MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY

DRUGINFO

Flufenamic Acid

DRUGINFO

ASP-9521

DRUGINFO

Beta-naphthylacetic acids derivative 1

DRUGINFO

Indomethacin analog 1

DRUGINFO

Indomethacin analog 2

DRUGINFO

Indomethacin analog 3

DRUGINFO

Isoquinolone derivative 1

DRUGINFO

N-(benzimidazole/indole) benzoic acid derivative 1