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靶点信息20(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Platelet glycoprotein VI (GP6)
TARGTYPE
Clinical trial target
SYNONYMS
Glycoprotein 6; GPVI
FUNCTION
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
PDBSTRUC
5OU9; 5OU8; 5OU7; 2GI7
SEQUENCE
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
KEGGPATH
hsa04512:ECM-receptor interaction
KEGGPATH
hsa04611:Platelet activation
WIKIPATH
WP1794:Cell surface interactions at the vascular wall
WIKIPATH
WP1826:GPVI-mediated activation cascade
WIKIPATH
WP1883:Platelet Adhesion to exposed collagen
REACPATH
R-HSA-114604:GPVI-mediated activation cascade
REACPATH
R-HSA-202733:Cell surface interactions at the vascular wall
REACPATH
R-HSA-75892:Platelet Adhesion to exposed collagen
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP1883 |
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| WP1826 |
|
| WP1794 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Platelet glycoprotein VI (GP6) |
|