TARGETID

T60182

FORMERID

TTDS00439

UNIPROID

GLR_HUMAN

TARGNAME

Glucagon receptor (GCGR)

GENENAME

GCGR

TARGTYPE

Successful target

SYNONYMS

GLR; GL-R

FUNCTION

Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis.

PDBSTRUC

5XEZ; 5EE7; 4LF3; 4L6R; 4ERS

BIOCLASS

GPCR secretin

SEQUENCE

MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF

DRUGINFO

Dasiglucagon

DRUGINFO

Glucagon recombinant

DRUGINFO

LGD-6972

DRUGINFO

LY-2409021

DRUGINFO

LY2944876

DRUGINFO

MK-8521

DRUGINFO

PF-06291874

DRUGINFO

REMD 477

DRUGINFO

TT-401