TARGETID

T57392

FORMERID

TTDS00475

UNIPROID

CP2D6_HUMAN

TARGNAME

Debrisoquine 4-hydroxylase (CYP2D6)

GENENAME

CYP2D6

TARGTYPE

Successful target

SYNONYMS

P450-DB1; Cytochrome P450-DB1; Cytochrome P450 2D6; CYPIID6; CYP2DL1

FUNCTION

It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.

PDBSTRUC

6CSD; 6CSB; 5TFU; 5TFT; 4XRZ

BIOCLASS

Paired donor oxygen oxidoreductase

ECNUMBER

EC 1.14.14.-

SEQUENCE

MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR

DRUGINFO

Glutethimide

DRUGINFO

ISOQUINE

DRUGINFO

(2-hydroxy-3-phenoxypropyl)(propan-2-yl)amine

DRUGINFO

(5-(pyridin-3-yl)furan-2-yl)methanamine

DRUGINFO

(5-phenylfuran-2-yl)methanamine

DRUGINFO

(5-pyridin-3-yl-furan-2-yl)methanethiol

DRUGINFO

1-(3,4-DICHLOROPHENYL)-6-(METHOXYMETHYL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX)

DRUGINFO

1-(4-Butoxy-phenyl)-1H-imidazole