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靶点信息31(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Dickkopf-related protein 1 (DKK1)
TARGTYPE
Clinical trial target
SYNONYMS
hDkk1; hDkk-1; UNQ492/PRO1008; Dkk1; Dkk-1; Dickkopfrelated protein 1; Dickkopf1; Dickkopf-1
FUNCTION
DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6.
PDBSTRUC
5GJE; 5FWW; 3SOQ; 3S8V; 3S2K
BIOCLASS
Dickkopf protein
SEQUENCE
MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
KEGGPATH
hsa04310:Wnt signaling pathway
WIKIPATH
WP2406:Cardiac Progenitor Differentiation
WIKIPATH
WP2572:Primary Focal Segmental Glomerulosclerosis FSGS
WIKIPATH
WP2840:Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WIKIPATH
WP2848:Differentiation Pathway
WIKIPATH
WP2853:Endoderm Differentiation
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP2857 |
|
| WP2853 |
|
| WP2848 |
|
| WP2840 |
|
| WP2572 |
|
| WP2406 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Dickkopf-related protein 1 (DKK1) |
|