靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T56510

FORMERID

TTDC00168

UNIPROID

B2CL1_HUMAN

TARGNAME

Apoptosis regulator Bcl-xL (BCL-xL)

GENENAME

BCL2L1

TARGTYPE

Clinical trial target

SYNONYMS

Bcl2like protein 1; Bcl2L1; Bcl2-L-1; Bcl-XL; Bcl-2-like protein 1; BCLX; BCL2L; Apoptosis regulator Bcl-X

FUNCTION

Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Potent inhibitor of cell death.

PDBSTRUC

6IJQ; 6F46; 6DCO; 6DCN; 6BF2

BIOCLASS

B-cell lymphoma Bcl-2

SEQUENCE

MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

DRUGINFO

ABT-263

DRUGINFO

Obatoclax

DRUGINFO

APG-1252

DRUGINFO

AZD0466

DRUGINFO

Indole-based analog 2

Patented

DRUGINFO

D0MZ7I

Indole-based analog 3

Patented

DRUGINFO

D0IS8R

PMID27744724-Compound-10

Patented

DRUGINFO

D0TU3N

PMID27744724-Compound-18

Patented

DRUGINFO

D0J9FN

PMID27744724-Compound-21

Patented

目标的 KEGG 通路数据

标题	内容
hsa04014	Ras signaling pathway
hsa04064	NF-kappa B signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04210	Apoptosis
hsa04630	Jak-STAT signaling pathway
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05145	Toxoplasmosis
hsa05166	HTLV-I infection
hsa05200	Pathways in cancer
hsa05202	Transcriptional misregulation in cancer
hsa05212	Pancreatic cancer
hsa05220	Chronic myeloid leukemia
hsa05222	Small cell lung cancer

目标的 Wiki 路径数据

标题	内容
WP364	IL-6 signaling pathway
WP286	IL-3 Signaling Pathway
WP2763	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
WP254	Apoptosis
WP2447	Amyotrophic lateral sclerosis (ALS)
WP231	TNF alpha Signaling Pathway
WP205	IL-7 Signaling Pathway
WP2034	Leptin signaling pathway
WP1841	Intrinsic Pathway for Apoptosis
WP1772	Apoptosis Modulation and Signaling

目标的蛋白质ID

标题	内容
TARGETID	T56510
UNIPROID	B2CL1_HUMAN
TARGNAME	Apoptosis regulator Bcl-xL (BCL-xL)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Apoptosis regulator Bcl-xL (BCL-xL)	MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

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