靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T52450

FORMERID

TTDC00147

UNIPROID

MMP1_HUMAN

TARGNAME

Matrix metalloproteinase-1 (MMP-1)

GENENAME

MMP1

TARGTYPE

Successful target

SYNONYMS

Interstitial collagenase; Fibroblast collagenase; CLG

FUNCTION

Cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Cleaves collagens of types I, II, and III at one site in the helical domain.

PDBSTRUC

966C; 4AYK; 4AUO; 3SHI; 3AYK

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.24.7

SEQUENCE

MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

DRUGINFO

Prinomastat

DRUGINFO

CIPEMASTAT

DRUGINFO

Marimastat

DRUGINFO

Apratastat

DRUGINFO

PMID29130358-Compound-Figure10(2a)

Patented

DRUGINFO

D0X6GG

PMID29130358-Compound-Figure18(14a)

Patented

DRUGINFO

D01EUF

BMS 275291

Discontinued in Phase 3

DRUGINFO

D0T9HG

GM6001

Discontinued in Phase 2

目标的 KEGG 通路数据

标题	内容
hsa03320	PPAR signaling pathway
hsa05200	Pathways in cancer
hsa05219	Bladder cancer
hsa05323	Rheumatoid arthritis

目标的 Wiki 路径数据

标题	内容
WP366	TGF beta Signaling Pathway
WP2828	Bladder Cancer
WP2769	Activation of Matrix Metalloproteinases
WP2708	Degradation of collagen
WP2435	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
WP2374	Oncostatin M Signaling Pathway
WP2263	Prostate Cancer
WP1984	Integrated Breast Cancer Pathway
WP1971	Integrated Cancer pathway
WP1794	Cell surface interactions at the vascular wall
WP129	Matrix Metalloproteinases

目标的蛋白质ID

标题	内容
TARGETID	T52450
UNIPROID	MMP1_HUMAN
TARGNAME	Matrix metalloproteinase-1 (MMP-1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Matrix metalloproteinase-1 (MMP-1)	MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

标题

内容

Matrix metalloproteinase-1 (MMP-1)

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