TARGETID

T48873

FORMERID

TTDS00118

UNIPROID

VMAT2_HUMAN

TARGNAME

Synaptic vesicle amine transporter (SLC18A2)

GENENAME

SLC18A2

TARGTYPE

Successful target

SYNONYMS

Vesicular amine transporter; Vesicular Monoamine Transporter; VMAT; VAT; Solute carrier family 18 member 2; SLC18A2; Monoamine transporter

FUNCTION

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

BIOCLASS

Major facilitator superfamily

SEQUENCE

MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD

DRUGINFO

Alkavervir

DRUGINFO

Alseroxylon

DRUGINFO

Deutetrabenazine

DRUGINFO

Reserpine

DRUGINFO

Tetrabenazine

DRUGINFO

Valbenazine Tosylate

DRUGINFO

Ingrezza

DRUGINFO

AV 133

DRUGINFO

NBI-98854

DRUGINFO

Lobeline