TARGETID

T47094

FORMERID

TTDS00194

UNIPROID

NK1R_HUMAN

TARGNAME

Substance-P receptor (TACR1)

GENENAME

TACR1

TARGTYPE

Successful target

SYNONYMS

Tachykinin receptor 1; Tachykinin neurokinin 1 receptor; Tachykinin 1 receptor; TACR1; Substance P receptor; SPR; Neurokinin 1 receptor; NK-1R; NK-1 receptor

FUNCTION

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

PDBSTRUC

6HLP; 6HLO; 6HLL; 6.00E+59; 2KSB

BIOCLASS

GPCR rhodopsin

SEQUENCE

MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS

DRUGINFO

Aprepitant

DRUGINFO

Palonosetron + fosnetupitant

DRUGINFO

Rolapitant

DRUGINFO

Selegiline

DRUGINFO

LY-686017

DRUGINFO

Netupitant

DRUGINFO

Serlopitant

DRUGINFO

CP-122721

DRUGINFO

DAPITANT