TARGETID

T46365

FORMERID

TTDR00116

UNIPROID

MPIP2_HUMAN

TARGNAME

M-phase inducer phosphatase 2 (MPIP2)

GENENAME

CDC25B

TARGTYPE

Clinical trial target

SYNONYMS

Dual specificity phosphatase Cdc25B; Cdc25B phosphatase; CDC25HU2

FUNCTION

Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.

PDBSTRUC

4WH9; 4WH7; 3FQU; 3FQT; 2UZQ

BIOCLASS

Phosphoric monoester hydrolase

ECNUMBER

EC 3.1.3.48

SEQUENCE

MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ

DRUGINFO

Avastin+/-Tarceva

DRUGINFO

MX-7065

DRUGINFO

2-Sulfhydryl-Ethanol

DRUGINFO

3-isopropyl-4-(phenylamino)naphthalene-1,2-dione

DRUGINFO

3-isopropyl-4-(phenylthio)naphthalene-1,2-dione

DRUGINFO

3-isopropyl-4-phenylnaphthalene-1,2-dione

DRUGINFO

4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione

DRUGINFO

4-ethoxynaphthalene-1,2-dione