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靶点信息39(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
TNF related apoptosis inducing ligand (TNFSF10)
TARGTYPE
Clinical trial target
SYNONYMS
Tumor necrosis factor ligand superfamily member 10; TRAIL; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253; Apo-2L; Apo-2 ligand; APO2L
FUNCTION
Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG.
PDBSTRUC
5CIR; 4N90; 1DU3; 1DG6; 1D4V
BIOCLASS
Cytokine: tumor necrosis factor
SEQUENCE
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04068:FoxO signaling pathway
KEGGPATH
hsa04210:Apoptosis
KEGGPATH
hsa04650:Natural killer cell mediated cytotoxicity
KEGGPATH
hsa05162:Measles
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04068 |
|
| hsa04210 |
|
| hsa04650 |
|
| hsa05162 |
|
| hsa05164 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP254 |
|
| WP1814 |
|
| WP1772 |
|
| WP1742 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| TNF related apoptosis inducing ligand (TNFSF10) |
|