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靶点信息16(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
V-set and immunoglobulin domain-containing protein 9 (TIGIT)
TARGTYPE
Clinical trial target
SYNONYMS
VSTM3; VSIG9; V-set and transmembrane domain-containing protein 3; T-cell immunoreceptor with Ig and ITIM domains
FUNCTION
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
PDBSTRUC
5V52; 3UDW; 3UCR; 3RQ3; 3Q0H
SEQUENCE
MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFFTETG
KEGGPATH
hsa04514:Cell adhesion molecules (CAMs)
目标的蛋白质ID
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目标的序列数据
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| V-set and immunoglobulin domain-containing protein 9 (TIGIT) |
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