REACPATH

R-HSA-936964:Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

REACPATH

R-HSA-937039:IRAK1 recruits IKK complex

REACPATH

R-HSA-937041:IKK complex recruitment mediated by RIP1

REACPATH

R-HSA-975144:IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

TARGETID

T32335

FORMERID

TTDC00222

TARGNAME

Inhibitor of nuclear factor kappa-B kinase (IKK)

TARGTYPE

Patented-recorded target

SYNONYMS

IB kinase; IkappaB kinase; IKK

FUNCTION

Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators sincethey exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

DRUGINFO

Dihydrothieno [2,3-e]indazole derivative 1

DRUGINFO

Dihydrothieno [2,3-e]indazole derivative 2

DRUGINFO

Dihydrothieno [2,3-e]indazole derivative 3

DRUGINFO

Dihydrothieno [2,3-e]indazole derivative 4

DRUGINFO

4-hydroxy-2-nonenal

DRUGINFO

5-Bromo-6-methoxy-9H-beta-carboline

DRUGINFO

Arsenite

DRUGINFO

BMS-345541

DRUGINFO

MLN-120B

DRUGINFO

MRT67307