TARGETID

T28722

FORMERID

TTDI01774

UNIPROID

GBRG3_HUMAN

TARGNAME

GABA(A) receptor gamma-3 (GABRG3)

GENENAME

GABRG3

TARGTYPE

Successful target

SYNONYMS

GABRG3

FUNCTION

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functionsas receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.

BIOCLASS

Ligand-gated ion channel

SEQUENCE

MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL

DRUGINFO

Allopregnanolone

DRUGINFO

Bentazepam

DRUGINFO

Clobazam - Lundbeck

DRUGINFO

Etomidate

DRUGINFO

Flumazenil

DRUGINFO

Mebutamate

DRUGINFO

Metharbital

DRUGINFO

Remimazolam

DRUGINFO

Stiripentol

DRUGINFO

Talbutal