TARGETID

T28692

FORMERID

TTDS00066

UNIPROID

LIPL_HUMAN

TARGNAME

Lipoprotein lipase (LPL)

GENENAME

LPL

TARGTYPE

Successful target

SYNONYMS

LIPD

FUNCTION

Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. Key enzyme in triglyceride metabolism.

PDBSTRUC

6OB0; 6OAZ; 6OAU; 6E7K

BIOCLASS

Carboxylic ester hydrolase

ECNUMBER

EC 3.1.1.34

SEQUENCE

MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG

DRUGINFO

Clofibrate

DRUGINFO

Gemfibrozil

DRUGINFO

AMT-011

DRUGINFO

Ibrolipim

DRUGINFO

WS-070117

KEGGPATH

hsa00561:Glycerolipid metabolism

KEGGPATH

hsa03320:PPAR signaling pathway

KEGGPATH

hsa05010:Alzheimer's disease