TARGETID

T28661

FORMERID

TTDS00389

UNIPROID

TBB2A_HUMAN

TARGNAME

Tubulin beta-2 chain (TUBB2)

GENENAME

TUBB2A

TARGTYPE

Successful target

SYNONYMS

Tubulin beta-2A chain; Tubulin beta class IIa; TUBB4B; BetaII-Tubulin; Beta(II)-Tubulin; Beta(II) isotype of Tubulin

FUNCTION

It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Tubulin is the major constituent of microtubules.

SEQUENCE

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

DRUGINFO

Vinblastine

DRUGINFO

DOLASTATIN-10

DRUGINFO

2,3'-diamino-3,4,4',5-tetramethoxy-(Z)-stillbene

DRUGINFO

2'-amino-3,4,4',5-tetramethoxy-(Z)-stillbene

DRUGINFO

2-amino-3,4',5-trimethoxy-(Z)-stillbene

DRUGINFO

3,4,4',5-tetramethoxy-(Z)-stilbene

DRUGINFO

3,4',5-trimethoxy-(Z)-stilbene

DRUGINFO

3-bromo-4,4',5-trimethoxy-(Z)-stilbene

DRUGINFO

6-ile-ustiloxin

DRUGINFO

N-(4-(3-(pyridin-2-yl)acryloyl)phenyl)acetamide

DRUGINFO

USTILOXIN A