TARGETID

T27812

FORMERID

TTDC00255

UNIPROID

SC6A4_HUMAN

TARGNAME

Serotonin transporter (SERT)

GENENAME

SLC6A4

TARGTYPE

Successful target

SYNONYMS

Solute carrier family 6 member 4; HTT; 5HTT; 5HT transporter

FUNCTION

Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization.

PDBSTRUC

6DZZ; 6DZY; 6DZW; 6DZV; 6AWQ

BIOCLASS

Neurotransmitter:sodium symporter

SEQUENCE

METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV

DRUGINFO

Acetaminophen

DRUGINFO

Amfepramone

DRUGINFO

Amitriptyline

DRUGINFO

Bupropion

DRUGINFO

Chlorphentermine Hydrochloride

DRUGINFO

Citalopram

DRUGINFO

Clomipramine

DRUGINFO

Cocaine

DRUGINFO

Dasotraline