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靶点信息

标题

内容

相关药物

状态

TARGETID

T27611

FORMERID

TTDI02218

UNIPROID

GDF2_HUMAN

TARGNAME

Growth/differentiation factor 2 (GDF2)

GENENAME

GDF2

TARGTYPE

Clinical trial target

SYNONYMS

GDF2; Bone morphogenetic protein 9; BMP9

FUNCTION

Potent circulating inhibitor of angiogenesis. Couldbe involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.

PDBSTRUC

5I05; 5HZW; 4YCI; 4YCG; 4MPL

BIOCLASS

Growth factor

SEQUENCE

MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR

DRUGINFO

D0N9PL

ACE-041

Phase 1

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T27611
UNIPROID	GDF2_HUMAN
TARGNAME	Growth/differentiation factor 2 (GDF2)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Growth/differentiation factor 2 (GDF2)	MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR

标题

内容

Growth/differentiation factor 2 (GDF2)

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