TARGETID

T26500

FORMERID

TTDR01193

UNIPROID

HRH4_HUMAN

TARGNAME

Histamine H4 receptor (H4R)

GENENAME

HRH4

TARGTYPE

Clinical trial target

SYNONYMS

SP9144; Pfi-013; HH4R; H4 receptor; GPRv53; GPCR105; G protein-coupled receptor 105; AXOR35

FUNCTION

Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS

DRUGINFO

JNJ-38518168

DRUGINFO

PF-3893787

DRUGINFO

UR-63325

DRUGINFO

Thioperamide

DRUGINFO

(1H-indol-2-yl)(piperazin-1-yl)methanone

DRUGINFO

(R)-3-(1H-imidazol-4-yl)propyl sec-butylcarbamate

DRUGINFO

(R)-alpha-methylhistamine

DRUGINFO

(S)-alpha-methylhistamine

DRUGINFO

[125I]iodophenpropit

DRUGINFO

[3H]JNJ 7777120