TARGETID

T25703

FORMERID

TTDC00134

UNIPROID

HMOX1_HUMAN

TARGNAME

Heme oxygenase 1 (HMOX1)

GENENAME

HMOX1

TARGTYPE

Clinical trial target

SYNONYMS

HO1; HO-1; HO

FUNCTION

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

PDBSTRUC

6EHA; 5BTQ; 4WD4; 3TGM; 3K4F

BIOCLASS

Paired donor oxygen oxidoreductase

ECNUMBER

EC 1.14.14.18

SEQUENCE

MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM

DRUGINFO

Stannsoporfin

DRUGINFO

1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone

DRUGINFO

12-Phenylheme

DRUGINFO

2-Phenylheme

DRUGINFO

2-Propanol, Isopropanol

DRUGINFO

Biliverdine Ix Alpha

DRUGINFO

Formic Acid

DRUGINFO

Heme