靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T14582

FORMERID

TTDR00158

UNIPROID

ALR_MYCSM

TARGNAME

Mycobacterium Biosynthetic alanine racemase (MycB alr)

GENENAME

MycB alr

TARGTYPE

Successful target

SYNONYMS

D-alanine racemase; Alr; Alanine racemase; AlaR

FUNCTION

Catalyzes the interconversion of L-alanine and D- alanine. Overexpression due to a natural mutation in the promoter is responsible for mediating resistance to D-cycloserine (DCS) in mycobacteria.

BIOCLASS

Racemases and epimerases

ECNUMBER

EC 5.1.1.1

SEQUENCE

MQTTEPMTPPAPLASAQTVIDLGAIDHNVRVLRELAGSADVMAVVKADAYGHGALPVARTALAAGAAALGVATIPEALALREGGITAPVLAWLHPPGTDFAPAIAADVEVAVSSRRQLEQVTAAAAEVGRTATVTVKVDTGLSRNGVGAADYPEVLDVLRRAQADGAIRVRGLMSHLVHGDDPENPFNGLQGQRLADMRVYAREHGVDYEVAHLCNSPAAMTRPDLAFEMVRPGISLYGLSPIPERGDMGLRPAMTLKCPVALVRSVHAGDGVSYGHRWVADRDTTLGLLPIGYADGVYRALSGRIDVLIKGRRRRAVGRICMDQFVVDLGPDADDVAVGDDAILFGPGANGEPTAQDWAELLDTIHYEVVTSPRGRVTRTYLPAGQQD

DRUGINFO

Cycloserine

DRUGINFO

3-fluorovinylglycine

DRUGINFO

Acetate Ion

DRUGINFO

Lysine Nz-Carboxylic Acid

Investigative

DRUGINFO

D0I7PG

N-(5'-Phosphopyridoxyl)-D-Alanine

DRUGINFO

Propanoic Acid

DRUGINFO

Propionate

DRUGINFO

Pyridoxamine-5'-Phosphate

Investigative

DRUGINFO

D0J1AY

Pyridoxyl-Alanine-5-Phosphate

Investigative

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T14582
UNIPROID	ALR_MYCSM
TARGNAME	Mycobacterium Biosynthetic alanine racemase (MycB alr)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Mycobacterium Biosynthetic alanine racemase (MycB alr)	MQTTEPMTPPAPLASAQTVIDLGAIDHNVRVLRELAGSADVMAVVKADAYGHGALPVARTALAAGAAALGVATIPEALALREGGITAPVLAWLHPPGTDFAPAIAADVEVAVSSRRQLEQVTAAAAEVGRTATVTVKVDTGLSRNGVGAADYPEVLDVLRRAQADGAIRVRGLMSHLVHGDDPENPFNGLQGQRLADMRVYAREHGVDYEVAHLCNSPAAMTRPDLAFEMVRPGISLYGLSPIPERGDMGLRPAMTLKCPVALVRSVHAGDGVSYGHRWVADRDTTLGLLPIGYADGVYRALSGRIDVLIKGRRRRAVGRICMDQFVVDLGPDADDVAVGDDAILFGPGANGEPTAQDWAELLDTIHYEVVTSPRGRVTRTYLPAGQQD

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