TARGETID

T14342

FORMERID

TTDS00317

UNIPROID

POL_HV1B1

TARGNAME

Human immunodeficiency virus Reverse transcriptase (HIV RT)

GENENAME

HIV RT

TARGTYPE

Successful target

SYNONYMS

HIV p66 RT; HIV Exoribonuclease H

FUNCTION

Gag-Pol polyprotein: Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shut off translation.

PDBSTRUC

6OE3; 6HAK; 6ELI; 6DUH; 6DUG

ECNUMBER

EC 2.7.7.49

SEQUENCE

PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKIL

DRUGINFO

Abacavir

DRUGINFO

Adefovir Dipivoxil

DRUGINFO

Bictegravir, emtricitabine and tenofovir alafenamide

DRUGINFO

Delavirdine

DRUGINFO

Didanosine

DRUGINFO

Efavirenz

DRUGINFO

Emtricitabine

DRUGINFO

Etravirine

DRUGINFO

GS-7340