TARGETID

T13714

FORMERID

TTDR00421

UNIPROID

NR1H2_HUMAN

TARGNAME

Oxysterols receptor LXR-beta (NR1H2)

GENENAME

NR1H2

TARGTYPE

Clinical trial target

SYNONYMS

Ubiquitously-expressed nuclear receptor; Nuclear receptor subfamily 1 group H member 2; Nuclear receptor NER; Nuclear orphan receptor LXR-beta; NER; Liver X receptor beta; LXRbeta; LXRB

FUNCTION

Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity.

PDBSTRUC

5KYJ; 5KYA; 5JY3; 5I4V; 5HJP

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

DRUGINFO

VTB-38543

DRUGINFO

12,17-dehydroxyriccardin C

DRUGINFO

12-dehydroxyriccardin C

DRUGINFO

17-dehydroxyriccardin C

DRUGINFO

22R-hydroxycholesterol

DRUGINFO

24(S), 25-epoxycholesterol

DRUGINFO

24(S)-hydroxycholesterol

DRUGINFO

27-hydroxycholesterol

DRUGINFO

2-Benzyl-3-phenyl-7-(trifluoromethyl)-2H-indazole