靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T13260

FORMERID

TTDS00252

UNIPROID

CP19A_HUMAN

TARGNAME

Aromatase (CYP19A1)

GENENAME

CYP19A1

TARGTYPE

Successful target

SYNONYMS

P-450AROM; Estrogen synthetase; Estrogen synthase; Cytochrome P450 19A1; Cytochrome P-450AROM; CYPXIX; CYP19; CYAR; ARO1

FUNCTION

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

PDBSTRUC

5JL9; 5JL7; 5JL6; 5JKW; 5JKV

BIOCLASS

Paired donor oxygen oxidoreductase

ECNUMBER

EC 1.14.14.14

SEQUENCE

MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH

DRUGINFO

Aminoglutethimide

DRUGINFO

Anastrozole

DRUGINFO

Exemestane

DRUGINFO

FADROZOLE

DRUGINFO

Letrozole

DRUGINFO

Testolactone

DRUGINFO

Atamestane + Toremifene

Phase 3

DRUGINFO

D08UGX

LIAROZOLE

Phase 2/3

目标的 KEGG 通路数据

标题	内容
hsa00140	Steroid hormone biosynthesis
hsa01100	Metabolic pathways
hsa04913	Ovarian steroidogenesis

目标的 Wiki 路径数据

标题	内容
WP702	Metapathway biotransformation
WP465	Tryptophan metabolism
WP43	Oxidation by Cytochrome P450
WP34	Ovarian Infertility Genes
WP2749	Metabolism of steroid hormones and vitamin D
WP2035	FSH signaling pathway
WP1984	Integrated Breast Cancer Pathway
WP1879	Phase 1 - Functionalization of compounds

目标的蛋白质ID

标题	内容
TARGETID	T13260
UNIPROID	CP19A_HUMAN
TARGNAME	Aromatase (CYP19A1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Aromatase (CYP19A1)	MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH

标题

内容

Aromatase (CYP19A1)

最新招商产品更多>>