靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T13075

FORMERID

TTDI03079

UNIPROID

KC1A_HUMAN

TARGNAME

Casein kinase I alpha (CSNK1A1)

GENENAME

CSNK1A1

TARGTYPE

Clinical trial target

SYNONYMS

Casein kinase I isoform alpha; CKI-alpha; CK1

FUNCTION

It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.

PDBSTRUC

6GZD; 5FQD

BIOCLASS

Kinase

ECNUMBER

EC 2.7.11.1

SEQUENCE

MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF

DRUGINFO

BTX-A51

DRUGINFO

US9096594, 3

DRUGINFO

D-4476

DRUGINFO

IC261

DRUGINFO

PMID24900428C14

目标的 KEGG 通路数据

标题	内容

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T13075
UNIPROID	KC1A_HUMAN
TARGNAME	Casein kinase I alpha (CSNK1A1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Casein kinase I alpha (CSNK1A1)	MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF

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