靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T13057

FORMERID

TTDR01263

UNIPROID

PTN11_HUMAN

TARGNAME

Protein-tyrosine phosphatase SHP-2 (PTPN11)

GENENAME

PTPN11

TARGTYPE

Clinical trial target

SYNONYMS

Tyrosine-protein phosphatase non-receptor type 11; SHPTP2; SHP2; SHP-2; SH-PTP3; SH-PTP2; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D; PTP2C; PTP-2C; PTP-1D

FUNCTION

Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

PDBSTRUC

6MDD; 6MDC; 6MDB; 6MDA; 6MD9

BIOCLASS

Phosphoric monoester hydrolase

ECNUMBER

EC 3.1.3.48

SEQUENCE

MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR

DRUGINFO

JAB-3312

DRUGINFO

BBP-398

DRUGINFO

JAB-3068

DRUGINFO

RLY-1971

DRUGINFO

SAR442720

DRUGINFO

TNO155

DRUGINFO

NSC-87877

DRUGINFO

Dodecane-Trimethylamine

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04014	Ras signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04670	Leukocyte transendothelial migration
hsa04722	Neurotrophin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05168	Herpes simplex infection
hsa05205	Proteoglycans in cancer
hsa05211	Renal cell carcinoma
hsa05220	Chronic myeloid leukemia

目标的 Wiki 路径数据

标题	内容
WP69	TCR Signaling Pathway
WP619	Type II interferon signaling (IFNG)
WP585	Interferon type I signaling pathways
WP49	IL-2 Signaling Pathway
WP481	Insulin Signaling
WP437	EGF/EGFR Signaling Pathway
WP395	IL-4 Signaling Pathway
WP364	IL-6 signaling pathway
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP304	Kit receptor signaling pathway
WP286	IL-3 Signaling Pathway
WP2752	MyD88-independent cascade
WP2713	Signaling by SCF-KIT
WP2704	Interleukin-6 signaling
WP2678	Prolactin receptor signaling
WP2677	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
WP2653	PIP3 activates AKT signaling
WP2593	JAK/STAT
WP2526	PDGF Pathway
WP244	Alpha 6 Beta 4 signaling pathway
WP2380	BDNF signaling pathway
WP2374	Oncostatin M Signaling Pathway
WP2332	Interleukin-11 Signaling Pathway
WP23	B Cell Receptor Signaling Pathway
WP2263	Prostate Cancer
WP2253	Pilocytic astrocytoma
WP2203	TSLP Signaling Pathway
WP2034	Leptin signaling pathway
WP195	IL-1 signaling pathway
WP1916	Signaling by PDGF
WP1911	Signaling by FGFR
WP1910	Signaling by EGFR
WP1909	Signal regulatory protein (SIRP) family interactions
WP1885	Platelet homeostasis
WP1868	Netrin-1 signaling
WP1840	Interleukin-3, 5 and GM-CSF signaling
WP1835	Interferon alpha/beta signaling
WP1799	Costimulation by the CD28 family
WP1794	Cell surface interactions at the vascular wall
WP1591	Heart Development
WP127	IL-5 Signaling Pathway

目标的蛋白质ID

标题	内容
TARGETID	T13057
UNIPROID	PTN11_HUMAN
TARGNAME	Protein-tyrosine phosphatase SHP-2 (PTPN11)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Protein-tyrosine phosphatase SHP-2 (PTPN11)	MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR

标题

内容

Protein-tyrosine phosphatase SHP-2 (PTPN11)

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