TARGETID

T12475

FORMERID

TTDS00273

UNIPROID

GNRHR_HUMAN

TARGNAME

Gonadotropin-releasing hormone receptor (GNRHR)

GENENAME

GNRHR

TARGTYPE

Successful target

SYNONYMS

Hypothalamic gonadotropin-releasing hormone receptor; Gonadotrophin releasing hormone receptor; GnRH-R; GnRH receptor; GRHR

FUNCTION

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL

DRUGINFO

Abarelix

DRUGINFO

Cetrorelix

DRUGINFO

Degarelix

DRUGINFO

Elagolix sodium

DRUGINFO

Ganirelix

DRUGINFO

Gonadorelin

DRUGINFO

Leuprorelin acetate

DRUGINFO

Nafarelin

DRUGINFO

Relugolix

DRUGINFO

Triptorelin