参考文献的REF id

HBREF000123

参考相关的药草或成分的id

HERB003232_25092424

药草/成分

La Jiao;辣椒;Hot pepper;chili;fructus Capsici

参考相关的药草或成分的名称

HERB003232

PubMed记录的参考id

The capsaicin receptor TRPV1 as a novel modulator of neural precursor cell proliferation.

参考文献发表的期刊

The capsaicin receptor (TRPV1, transient receptor potential vanilloid type 1) was first discovered in the peripheral nervous system as a detector of noxious chemical and thermal stimuli including the irritant chili pepper. Recently, there has been increasing evidence of TRPV1 expression in the central nervous system. Here, we show that TRPV1 is expressed in neural precursor cells (NPCs) during postnatal development, but not in the adult. However, expression of TRPV1 is induced in the adult in paradigms linked to an increase in neurogenesis, such as spatial learning in the Morris water maze or voluntary exercise. Loss of TRPV1 expression in knockout mice leads to an increase in NPC proliferation. Functional TRPV1 expression has been confirmed in cultured NPCs. Our results indicate that TRPV1 expression influences both postnatal and activity-induced neurogenesis in adulthood.

参考的DOI

Stem Cells

论文中涉及的实验对象

12 1 2014 12:00AM

论文中涉及的实验类型

10.1002/stem.1805

动物实验

Mice

细胞实验

Animal Experiment

临床实验

Neural precursor cell proliferation

未详细提及

0