SMPDB_ID

SMP0000147

PW_ID

PW000225

图片

主题

Drug Action

描述

Benazepril, brand name Lotensin, belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a prodrug which, following oral administration, undergoes biotransformation in vivo into its active form benazeprilat via cleavage of its ester group by the liver. Angiotensin-converting enzyme (ACE) is a component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I into the active vasoconstrictor angiotensin II. ACE (or kininase II) also degrades the potent vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

代谢物

SMPDB ID	代谢物id	代谢物的名字
SMP0000147	PW_C009708	Cilazapril
SMP0000147	PW_C000374	Chloride ion
SMP0000147	PW_C001326	Vasopressin
SMP0000147	PW_C000026	Aldosterone
SMP0000147	PW_C000816	Angiotensin II
SMP0000147	PW_C040470	Angiotensin I
SMP0000147	PW_C001005	Zinc (II) ion
SMP0000147	PW_C040471	Cilazaprilat

蛋白质

SMPDB ID	蛋白质id	蛋白质的名字
SMP0000147	P30556	Type-1 angiotensin II receptor
SMP0000147	P01019	Angiotensinogen
SMP0000147	P00797	Renin
SMP0000147	P12821	Angiotensin-converting enzyme