SMPDB_ID

SMP0000071

PW_ID

PW000028

图片

主题

Metabolic

描述

Ketone bodies are consisted of acetone, beta-hydroxybutyrate and acetoacetate. In liver cells' mitochondria, acetyl-CoA can synthesize acetoacetate and beta-hydroxybutyrate; and spontaneous decarboxylation of acetoacetate will form acetone. Metabolism of ketone body (also known as ketogenesis) contains several reactions. Acetoacetic acid (acetoacetate) will be catalyzed to form acetoacetyl-CoA irreversibly by 3-oxoacid CoA-transferase 1 that also coupled with interconversion of succinyl-CoA and succinic acid. Acetoacetic acid can also be catalyzed by mitochondrial D-beta-hydroxybutyrate dehydrogenase to form (R)-3-Hydroxybutyric acid with NADH. Ketogenesis occurs mostly during fasting and starvation. Stored fatty acids will be broken down and mobilized to produce large amount of acetyl-CoA for ketogenesis in liver, which can reduce the demand of glucose for other tissues. Acetone cannot be converted back to acetyl-CoA; therefore, they are either breathed out through the lungs or excreted in urine.

代谢物

SMPDB ID	代谢物id	代谢物的名字
SMP0000071	PW_C001316	Carbon dioxide
SMP0000071	PW_C001212	Acetone
SMP0000071	PW_C001144	NADH
SMP0000071	PW_C000721	NAD
SMP0000071	PW_C000006	(R)-3-Hydroxybutyric acid
SMP0000071	PW_C000174	Succinic acid
SMP0000071	PW_C000808	Succinyl-CoA
SMP0000071	PW_C000042	Acetoacetic acid
SMP0000071	PW_C001063	3-Hydroxy-3-methylglutaryl-CoA
SMP0000071	PW_C001420	Water
SMP0000071	PW_C001099	Coenzyme A
SMP0000071	PW_C001142	Acetoacetyl-CoA
SMP0000071	PW_C000940	Acetyl-CoA

蛋白质

SMPDB ID	蛋白质id	蛋白质的名字
SMP0000071	Q02338	D-beta-hydroxybutyrate dehydrogenase, mitochondrial
SMP0000071	P55809	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
SMP0000071	P35914	Hydroxymethylglutaryl-CoA lyase, mitochondrial
SMP0000071	P54868	Hydroxymethylglutaryl-CoA synthase, mitochondrial
SMP0000071	P24752	Acetyl-CoA acetyltransferase, mitochondrial